Mycoplasma is weakly positive and usually requires 2 to 4 courses of azithromycin. If still can not turn negative, need to change to other antibiotics. Mycoplasma test shows weak positive, means that the patient is infected with mycoplasma, generally considered to be a sexually transmitted disease of the urinary system, usually need to take azithromycin 2~4 courses of treatment, the specific course of treatment needs to depend on the degree of improvement of the condition. Azithromycin is prone to drug resistance, so after 2 courses of treatment need to be reviewed, if still weakly positive, you can continue to take 2 courses of treatment. If it is still weakly positive, Azithromycin can no longer be taken, you need to change to erythromycin or clindamycin, and then review after 2~4 courses of treatment. Common adverse reactions to azithromycin include nausea, vomiting, diarrhea, diarrhea, anorexia, and abdominal discomfort, etc. Azithromycin is contraindicated for those who are allergic to azithromycin. In addition, azithromycin has certain risks associated with its administration, and patients need to be instructed by a specialist.