I have had many patients ask me if it is possible to fly with a skull defect. From a neurosurgical point of view, I do not recommend patients to travel by airplane, it is very dangerous for them and not a joke. Patients who have not repaired their cranial defects, their brain tissue lacks the protection of the skull, and the surface of the cerebral cortex is directly connected to the skin, so the external air-atmosphere pressure acts directly on the surface of the brain through the skin. During takeoff and landing, the change of air-atmosphere pressure in the cabin will produce some pressure and pull on the brain tissue directly through the skin in the skull defect area. In mild cases, patients may suffer from headaches, dizziness and nausea. However, if the pressure change is particularly large, it may produce more serious damage to the cerebral cortex, especially if the aircraft produces an emergency situation, the pressure change in the air cabin of the aircraft is so drastic that it may induce seizures. Therefore, patients with skull defects, especially those with large defects and no repair, are generally not recommended to take a flight, but if the patient has undergone skull repair and the condition has been stabilized, it is generally not a problem to take a flight at this time, but it also depends on the patient’s physical condition.