Wheezing is a common symptom in children, especially in infants and toddlers under 3 years of age, but determining whether it is asthma or what the chances of developing asthma in the future are tricky for parents and even pediatricians. Using the Asthma Prediction Index (API), we can make a preliminary determination. For children under 3 years of age with R4 wheezing episodes in a year, the risk of developing asthma is 4-6 times higher at 6-13 years of age if the API is positive, and 95% do not develop asthma if the API is negative. For high-risk infants and children with positive API, standardized treatment for asthma is recommended. Definition of API positive: having 1 major risk factor or 2 minor risk factors. The major risk factors are: 1) family history of asthma in parents, 2) physician-diagnosed atopic dermatitis, and 3) positive inhalation allergens. Secondary risk factors were: 1) evidence of food allergen sensitization, 2) peripheral blood eosinophil R4%, 3) wheezing unrelated to cold.