Intercostal neuralgia or cardiac pain can be determined by the symptoms, as a preliminary judgment, intercostal neuralgia pain is mostly persistent, while the pain caused by cardiac disease manifested as paroxysmal pain. 1.General intercostal neuralgia pain along the intercostal nerve travel, from the back of the thoracic vertebrae to the anterior chest in a semi-circular shape, can be located in one or more intercostal nerves, the boundaries are more obvious. The pain is cut-like, needle-like or burning pain, sometimes radiating to the back of the shoulder, and the pain will appear when pressing hard on the painful part. The pain is mostly persistent and aggravated by coughing, sneezing and deep inhalation. 2. The pain caused by heart disease is characterized by paroxysmal pain, which is related to activity, pain after activity, pain will disappear after rest, and there will be no pain when breathing deeply, coughing, or pressing the painful area with hands. 3. The treatment of intercostal neuralgia first needs to clarify the cause of the disease, the pain is serious can be given to relieve the symptoms of pain medication (such as carbamazepine, etc.). Closure therapy or surgery can also be performed if necessary. The general treatment for heart disease includes medication, interventional therapy, and surgical treatment. Both intercostal neuralgia and cardiac pain should be treated; patients are advised to consult a doctor in time to clarify the cause of the disease and then give targeted treatment.