The treatment of syphilis is related to the stage and type of syphilis, such as early and late syphilis with benzylpenicillin or procaine penicillin G, cardiovascular syphilis with benzylpenicillin, neurosyphilis with penicillin G, etc.. 1. Early syphilis: benzylpenicillin or procaine penicillin G, penicillin allergy can choose ceftriaxone sodium intramuscular injection or intravenous injection, or oral tetracycline drugs (such as tetracycline, doxycycline, etc.), penicillin or doxycycline treatment is ineffective can choose azithromycin. 2. Late syphilis: benzylpenicillin or procaine penicillin, penicillin allergy can use doxycycline. 3. Cardiovascular syphilis: first use benzylpenicillin. 4. Neurosyphilis: the first choice of aqueous penicillin G, followed by benzylpenicillin or procaine penicillin G intramuscular injection, at the same time oral probenecid, should also be oral prednisone. 5. Syphilis of pregnancy: oral erythromycin, doxycycline and azithromycin are prohibited. 6. Congenital syphilis: (1) early congenital syphilis: cerebrospinal fluid abnormalities in intravenous injection of aqueous penicillin or intramuscular injection of procaine penicillin G. Cerebrospinal fluid normal selection of benzylpenicillin. (2) Late congenital syphilis: aqueous penicillin or procaine penicillin G. Tetracycline is prohibited for children aged 8 years. Syphilis patients should not use their own medication, should go to the hospital in time, under the guidance of the doctor standardized treatment.