Perioral dermatitis requires laboratory testing for fungus in clinical treatment, as some patients have combined fungal infections. If fungal spores are seen, topical application of naftifine ketoconazole ointment or terbinafine hydrochloride gel can be applied. If it is negative, it means that the allergic factor is relatively large, and can be treated with oral Orotadine hydrochloride tablets or Epinastine hydrochloride capsules, combined with compound glycopyrrolate capsules, and topical application of Pimecrolimus ointment mixed with black bean distillate oil. If dermatitis breaks down, fusidic acid ointment or recombinant human bovine basic fibroblast growth factor gel can be applied to promote epidermal healing. During the treatment period, avoid alcohol, spicy and irritating foods, as well as hairy products such as beef, mutton and seafood.