Patients with membranous nephropathy are often ineffective with hormone therapy alone, and need to be co-treated with other immunosuppressants, with an onset of action ranging from weeks to months, with large individual variations. Glucocorticoid therapy alone is often ineffective in patients with membranous nephropathy, and combination of immunosuppressants such as cyclosporine, cyclophosphamide, tacrolimus, etc. is needed. The onset of action is highly dependent on the patient’s response to the drug and the individual’s condition. The fastest patients will have the effect within several weeks, while the slowest patients will need several months, and even the combination of hormone and immunosuppressant treatment is ineffective, at this time, it is necessary to change the other treatment options, such as the application of rituximab treatment. Patients with membranous nephropathy who have poor therapeutic effect need to actively find the reasons, such as drug concentration is not up to the standard, poor blood pressure control and so on. If the medication is still ineffective after eliminating various unfavorable factors, it is necessary to change the treatment plan under the guidance of physicians. It is recommended that patients with membranous nephropathy should go to the hospital in time and follow the doctor’s instructions, do not use drugs on their own.