The effectiveness and safety of the HPV bivalent vaccine approved and marketed are guaranteed, and there is little difference in the effectiveness of HPV bivalent vaccines from different manufacturers. HPV vaccine, also known as human papillomavirus vaccine, HPV bivalent vaccine, no matter which manufacturer produces, can prevent two high-risk subtypes of human papillomavirus, namely HPV16 and HPV18. Currently, there are both domestic and imported HPV bivalent vaccines available for women of the appropriate age to receive in China, and both vaccines produce similar protective effects. For the domestic HPV bivalent vaccine produced by different manufacturers, timely full vaccination can produce good immune effects. HPV bivalent vaccine is suitable for women aged 9-45 years old, and after vaccination, they still need to have a physical examination on time.