There is no such thing as the most effective medicine for kidney stones. Patients with kidney stones can take NSAIDs, opioid analgesics, and alpha blockers as prescribed by the doctor, such as aspirin tablets, pethidine hydrochloride tablets, and tamsulosin hydrochloride extended-release capsules. 1. Non-steroidal anti-inflammatory drugs: If patients with kidney stones have symptoms of renal colic, patients can take oral aspirin tablets, ibuprofen extended-release capsules, diclofenac sodium extended-release tablets and other non-steroidal anti-inflammatory drugs as prescribed by the doctor for pain relief treatment. 2. Opioid analgesics: patients with kidney stone pain can also take pethidine hydrochloride tablets, oxycodone hydrochloride tablets and other opioid analgesics as prescribed by the doctor, which have a good analgesic effect. 3. α-blockers: patients with kidney stones can also be prescribed to take tamsulosin hydrochloride extended-release capsules, terazosin hydrochloride tablets, doxazosin mesylate extended-release tablets and other α-blockers. α-blockers have an antispasmodic effect, which can relax the smooth muscle of the ureter and promote the discharge of stones. Patients with kidney stones do not have the fastest medication for stone removal, patients should seek timely medical attention and take medication as prescribed by the doctor.