It is advisable to go to the hospital for relevant examinations to clarify the causes: first, herpes virus infection, the majority of which is caused by unclean sexual contact. The infection is followed by clusters of small blisters on the glans, with a reddish base and significant pain. The blisters can gradually rupture spontaneously, forming a local vesicular surface after the rupture and creating local pain. Secondly, when glansitis occurs, there can be small blisters on the glans, accompanied by redness and swelling of the glans or increased secretions, or changes such as local erosion and erythema. It is recommended that relevant pathogenic tests such as bacterial smears, fungal smears or trichomonas smears be performed to further confirm the diagnosis. Thirdly, if there is excessive stimulation or excessive friction, small blisters on the glans may appear, which are usually solitary and large in size, with thin walls and can rupture spontaneously. The blisters can disappear on their own after stopping the relevant stimulation and friction factors.