Diffuse echogenic changes in the liver parenchyma suggest abnormalities in the anatomy of the liver, possible damage to the hepatocytes, and the possibility of cirrhosis cannot be ruled out. Nowadays, with the improvement of living standards, high-fat eating and fatty infiltration of the liver can suggest diffuse changes on imaging. There is usually no significant enhancement after enhancement, which can be distinguished, especially from malignant tumors. Cirrhosis, including viral, schistosomal, and drug-related, can have diffuse changes on imaging, and even nodular hyperplasia, which should be identified with the patient’s past medical history and clinical manifestations and imaging changes, and treated appropriately, even if the parenchymal echo has a tendency to reverse.