Staying up all night with acne can be treated through life conditioning, topical medication or oral medication. 1. Life management: patients should ensure a healthy diet, eat less high sugar, high fat, spicy and stimulating food, develop good habits, avoid staying up late. 2. Topical medication: patients who stay up all night with acne can also use topical medication under the guidance of a doctor, such as retinoic acid cream, benzoyl peroxide gel or fusidic acid cream and other medications to improve the treatment. 3. Oral drugs: If the therapeutic effect of topical drugs is not obvious, you can also choose oral drugs under the guidance of a doctor, such as minocycline, doxycycline, isotretinoin soft capsules and other drugs for treatment, but you need to be clear about the contraindications of the drug and precautions, to avoid blind use of medication to avoid the discomfort of the impact. Stay up all night long acne, first of all, should reduce or avoid staying up all night, and through the life conditioning to ease the improvement, if the improvement effect of the life conditioning is not obvious, should be timely to the hospital under the guidance of a professional doctor to choose the drug treatment, need to pay attention to do not blindly use the drug, to avoid misunderstanding the condition or cause other discomforts.