Atypical membranous nephropathy is usually not completely curable and requires lifelong medication. Atypical membranous nephropathy refers to other manifestations besides the typical glomerular basement membrane thickening, such as tethered cell hyperplasia. The more common causes are viral hepatitis B infection, systemic lupus erythematosus, drug intoxication, malignant tumors and so on. 1. Atypical membranous nephropathy caused by viral hepatitis B, need to follow the doctor’s advice to apply antiviral therapy, such as tenofovir and other drugs. 2. Patients with lupus nephritis can be treated with glucocorticoids and other immunosuppressants or cytotoxic drugs, such as prednisone, mertiomacrophenol ester, cyclophosphamide, etc., which can make the disease go into remission, but there is a possibility of recurrence, and it can’t be cured completely. 3. Atypical membranous nephropathy caused by malignant tumors is usually treated with symptomatic treatment as prescribed by the doctor, and usually cannot be cured completely. Atypical membranous nephropathy needs to actively search for the cause of the disease under the guidance of specialists, and then carry out the treatment of the cause, we suggest that the patients consult the doctor in time and follow the doctor’s instructions, so as to avoid delaying the condition.