Sudden epigastric pain in the middle of the night, which is quite severe, can be caused by a variety of reasons, and it is necessary to check the location of the pain and the accompanying symptoms. If there is acute left epigastric pain, it may be acute gastritis caused by stomach cramps; in addition, if you have a gastric ulcer or gastric perforation, it may also cause pain in the left epigastric region, in addition to acid reflux, heartburn, and other symptoms; if the patient is the right epigastric pain, it is considered that there may be pancreatitis, septic cholecystitis and other diseases. Therefore, patients with epigastric pain need to go to the hospital to check the ultrasound of the upper abdomen or abdominal CT, and also need to check the blood amylase, and need to exclude pancreatitis or gastric perforation, because this disease is more critical, and may endanger the patient’s life. Only complete the relevant examination, and according to the clinical symptoms of the comprehensive analysis can be clearly diagnosed, according to the cause of the targeted treatment.