Cranial defects need to be treated surgically after cranial defects both for appearance and safety reasons. Cranial bone repair surgery is of great significance to regain the closed structure of the cranial cavity, restore the normal cranial appearance of the patient, avoid accidental injury, relieve psychological stress and improve the quality of life of the patient. In recent years, as cranial repair surgery is widely used in neurosurgery, clinical insight into the widely used metal titanium and peek materials has also been gained. Titanium mesh does possess great advances compared with previous cranial repair materials, such as high corrosion resistance and resistance to body secretions. However, everything is a double-edged sword, and titanium mesh is no exception. Due to its poor histocompatibility, postoperative infections or rejection often occur, coupled with the overlay repair, the scalp tends to thin after surgery, and even more so, the titanium mesh is exposed. In addition, the titanium mesh is hard and can collapse and deform under the influence of external forces. Many patients with cranial defects have a crater in their forehead due to the collapse and deformation of the titanium mesh. What should I do if there is another pit in the skull repair surgery? Peek material is a more advanced material with less rejection and infection, which can be customized for each patient’s defective bone window with the assistance of 3D reconstruction and 3D printing. We adopt peek as the skull repair implant material, for the craniomaxillofacial self aesthetic aspect, also innovatively introduce the concept of aesthetic plastic surgery, to achieve the overall unity of aesthetic appearance and scalp sensory comfort. After years of clinical practice, we have continuously researched on the basis of hundreds of completed peek skull repair cases, and combined with domestic and foreign literature on trauma and neurosurgery, put forward the concept of medical-industrial combination, and continuously upgraded technology and material design optimization, and now we have four technical innovations. He has successfully completed the first case of titanium mesh removal and peek material implantation in China, and achieved satisfactory treatment results.