Inflammation of teeth with severe pain is usually a disease such as pericoronitis of wisdom teeth, gingivitis, endodontitis, apical periodontitis, and so on. Targeted treatment should be carried out for different diseases, including taking anti-infective drugs, analgesic drugs, peri-coronary rinsing and root canal treatment and other treatment methods. 1. Gingivitis patients often have toothache, bleeding gums, swollen gums and other symptoms, taking metronidazole, amoxicillin, roxithromycin and other antibiotics can be effective treatment of bacterial infections, but also need to carry out periodontal treatment, such as scaling and cleaning to remove plaque, calculus and other irritating factors. 2. Patients with severe toothache can choose to take ibuprofen, acetaminophen and other analgesic drugs to temporarily relieve pain. 3. Patients with pulpitis and periapical infections need to be treated with root canal therapy, which can remove the pulp that has been completely necrotic or has caused periapical infection. 4. Wisdom tooth peri-coronitis requires the use of saline, hydrogen peroxide alternately for peri-coronary rinsing, oral metronidazole, cephalosporin and other antibiotics for anti-inflammatory treatment, and consider removing the wisdom teeth after the inflammation is under control. Toothache should be timely medical examination and treatment, the use of drugs need to follow the doctor’s instructions.