The causes of developmental epileptic encephalopathy include organic damage, inborn metabolic defects and genetic inheritance. 1. Organic damage: Organic damage such as brain penetrating malformation, megalencephaly and cortical dysplasia is the main cause of developmental epileptic encephalopathy, which is usually caused by perinatal trauma or accidental injuries during delivery, resulting in extensive brain damage, resulting in brain maturation disorders, and disorders in the connection between subcortical tissues and the cortex. 2. Inborn metabolic defects: mitochondria-related metabolic enzymes or other metabolism-related enzymatic abnormalities can also cause developmental epileptic encephalopathy. 3. Genetic inheritance: Patients with a family history of epilepsy are at some risk for genetic abnormalities, which are usually congenital, difficult to treat, and have a poor prognosis. The causes of developmental epileptic encephalopathy are complex, so it is necessary to go to a regular hospital for diagnosis and treatment.