Irregularities in the walls of the coronary arteries suggest the possible formation of coronary atheromatous plaques. Coronary arteries are important blood vessels supplying the heart muscle, including the left and right coronary arteries. Long-term high-fat and high-cholesterol diets, inflammatory diseases of the heart or after surgery can easily cause lipid deposition in the blood vessels, resulting in atheromatous plaques and damage to the endothelial cells of the blood vessels. After the formation of coronary atheromatous plaque, coronary CT examination or coronary angiography can be found in the coronary artery vessel wall irregularity, which will cause the inner diameter of the vessel significantly narrowed. When the coronary artery narrowing affects the blood supply to the heart muscle, it is easy to induce angina pectoris, and it is also easy to form blood clots later, which is a high risk factor for myocardial infarction. Patients with irregular coronary artery walls are advised to consult the cardiology department as soon as possible to improve the relevant examinations to clarify the cause of the disease and the current condition. Patients with less serious conditions are recommended to take secondary prevention under the guidance of a doctor, such as medication to control blood pressure, blood lipids, blood sugar, etc., and regular cardiac review.