Fruit acids have gained positive results as chemotherapy in acne treatment. Fruit acids are widely found in fruits, sugar cane, and yogurt. They have a simple molecular structure, small molecular weight, are non-toxic and odorless, and have strong permeability and safe action. Its mechanism of action is to reduce the adhesion of keratin-forming cells by interfering with the binding force of cell surface, accelerate the shedding and renewal of epidermal cells, regulate the secretion of sebaceous glands, and stimulate the synthesis of dermal collagen, increase mucopolysaccharide and promote tissue repair. Treatment protocol: Application of glycolic acid (also known as glycolic acid, derived from sugar cane) at concentrations of 20%, 35%, 50%, and 70% for acne treatment, with increasing concentrations or dwell time depending on the patient’s tolerance level. Treatment is given once every 2-4 weeks, with 4 sessions being a course of treatment. Increasing the number of treatments may improve the efficacy. It is effective for both inflammatory and non-inflammatory lesions. After fruit acid treatment, localized light erythema, white cream, swelling, stinging and burning sensation may appear, all of which can be recovered within 3-5 d. If post-inflammatory pigmentation occurs, it will take 3-6 months to recover. Pay attention to sun protection during the inter-treatment period.