The skull is an important structure that protects brain tissue. For growing children, the role of the skull is particularly important. Once the cranium is lost due to various accidents, children will face both psychological and physiological damage, which is detrimental to the healthy growth of children. Parents of children with cranial bone damage due to various accidents are most concerned about what cranial bone repair material will not affect the growth and development of the child and can quickly treat the condition. What is the best material for skull repair in children? The main cranial repair materials used in clinical practice are the more traditional titanium mesh and the new polyetheretherketone PEEK material. Compared to these two materials, polyetheretherketone PEEK has superior performance, better matching the human environment, higher strength, better protection, and better shaping, so it is a wiser and more desirable choice for both adult and pediatric cranial defect patients to use polyetheretheretherketone PEEK for cranial repair. The use of PEEK for cranial repair of cranial defects in children is ideal, and the performance of polyetheretherketone PEEK is excellent for achieving better repair results. Therefore, it is recommended that patients choose the right material to repair their skull when they undergo cranial repair, so that they can restore their health as soon as possible.