Tongue-shaped orange-red mucosa in the cardia may indicate Barrett’s esophagitis. Tongue-shaped orange-red mucosa in the cardia is a pathological phenomenon that refers to the replacement of the complex squamous epithelium of the lower esophagus by a single layer of columnar epithelium with metaplasia, which may be accompanied by intestinal epithelial metaplasia. This phenomenon is called Barrett’s esophagitis, which is triggered by chronic gastroesophageal reflux disease (GERD), and it belongs to a kind of pre-cancerous lesion. If not treated in time, it is easy to develop into esophageal adenocarcinoma. Patients should pay attention to ensure good living habits, not to stay up late or get angry, and reasonably apply drugs to inhibit gastric acid and protect esophageal mucosa for treatment, such as omeprazole, magnesium alumina carbonate, and so on. It is also necessary to carry out regular examination of Helicobacter pylori to kill Helicobacter pylori, which is conducive to the recovery of the condition. The above drugs should be used under the guidance of professional physicians. When the above situation occurs, you should seek medical treatment in time and get treated as early as possible under the guidance of professional physicians.