The preferred drug treatment for refractory hypertension is the triple combination of renin-angiotensin system inhibitors, calcium antagonists and thiazide diuretics. First of all, recalcitrant hypertension is mainly due to the combination of three or more drugs can not achieve the goal of lowering blood pressure, most of the cases of blood pressure is difficult to control, so in the choice of drugs should be preferred to use a combination of drugs, in order to control the recalcitrant hypertension; Renin-angiotensin system inhibitors, combined calcium antagonists, and then combined with thiazide diuretics (representative drugs are: enalapril or valsartan, nifedipine, hydrochlorothiazide, etc.), the combined use of the three types of drugs can expand the arterial and venous system while effectively reducing blood volume, thus playing a joint antihypertensive purpose in the treatment of recalcitrant hypertension, the clinical efficacy of the more significant so as the first choice. The use of drugs. Renal artery stenosis patients are not allowed to use renin – angiotensin system inhibitors, gout patients can not use thiazide diuretics, combined with the use of calcium antagonists may appear after the lower limbs edema, rapid heartbeat; facial flushing, attention to the matter of the above situation, it is recommended to consult a doctor in a timely manner. However, persistent hypertension through drug treatment if not yet controlled, it is necessary to consider some secondary factors caused by persistent hypertension, need to do further relevant examinations to get good control, so it is recommended that patients according to their own blood pressure status under the guidance of a physician to choose a reasonable drug therapy, not blindly use their own medication.