HPV53 positive men, no symptoms do not need to use drugs, if there are common warts, warts, can be used externally tincture of onychomycosis, imiquimod cream, systemic drugs can choose immunomodulators such as interferon, thymus peptide and so on. 1. not need to use the situation: male HPV53 positive, if it is a hidden infection, the body does not have symptoms, is not the need to use drugs, more exercise, pay attention to personal hygiene, most of the virus will be cleared by themselves, will be the self. 2. Topical medications: Commonly used medications include tincture of colchicine, imiquimod cream, and fluorouracil cream. 3. Systemic medication: Currently there is no specific anti-viral drug for HPV, you can choose interferon, thymidine, transfer factor and other immunomodulators for adjuvant treatment. If there are symptoms, in addition to medication, you can also use physical therapy such as cryotherapy, laser therapy, etc. to remove warts. Men who are HPV53 positive need to go to the hospital in time for examination, and the drugs need to be used under the guidance of a professional doctor.