Sepsis fever usually lasts about 5 to 14 days, the exact time is related to the severity of the disease. 1. General condition: it usually takes about 5 to 7 days for the fever to subside; if sepsis occurs, antibiotic treatment, such as azithromycin, ceftriaxone, and hydrocortisone, needs to be applied. 2. Serious condition: it may take two weeks for the fever to go down, or even longer, and some patients may endanger their lives if septic shock occurs; in addition, they need to receive anti-infective treatments, such as the third-generation cephalosporin combined with vancomycin, carbapenem antibiotics; in addition, they need to receive rehydration treatments to maintain the stability of blood volume. In addition, the application of all the above drugs have certain risks, patients need to be under the guidance of specialists.