Multiple meningiomas of the brain are mostly disseminated cases, although the exact cause of the occurrence of this group of cases is not clear. However, some are associated with definite genetic mutations, and neurofibromatosis is one of these common conditions. Patients can develop not only meningiomas, but also multiple meningiomas, and even other tumors in multiple other areas such as the eye and skin. Xiao Lin, 16 years old, had a gradual loss of vision in her right eye 3 years ago, and no specific cause was found locally. 1 year ago, while traveling with her parents, she gradually developed no strength in her legs during the trip until she finally couldn’t walk. Her family rushed her to the largest local hospital, where an MRI revealed a tumor in the spinal canal, and the pathology was diagnosed as a spinal meningioma after surgery. But it was also at this time that Xiaolin also found tumors in her eyes and brain at the same time! But as Lin’s post-surgery leg activity improved, she returned to her hometown to recuperate temporarily. However, half a year later, Xiao Lin had dizziness and headache again. A repeat brain MRI showed that there were two tumors in her brain, and the volume had increased significantly compared with the MRI six months ago, indicating that the tumors were growing rapidly. This time, the tumor in Xiaolin’s brain had to be dealt with. Xiao Lin underwent resection of brain tumors. Fortunately, the two tumors in Xiao Lin’s brain were relatively close to each other, and through a narrow channel of surgical incision, the two tumors in the brain could be removed at the same time under the microscope at one time. Under the care of the medical staff, Xiao Lin recovered quickly after the surgery. Although both tumors in the brain are WHO grade 1 benign meningiomas, the pathological subtypes diagnosed pathologically are different, one is dermatocellular type and the other is transitional type. The threat of tumor in Xiaolin’s brain was successfully removed by microsurgical resection. Neurofibromatosis is a common neurocutaneous disease that often occurs in different parts of the body with multiple or multiple tumors and is tricky to treat. When neurofibromatosis is suspected, a thorough examination is needed to look for possible tumors in other parts of the body, and multiple disciplines, including neurosurgery, work together to develop the best treatment plan.