Megakaryocyte maturation disorder is often considered a typical change in bone marrow examination of idiopathic thrombocytopenic purpura (ITP). In clinical work, it is found that diseases such as connective tissue disease, hypersplenism, and megaloblastic anemia can also manifest as peripheral thrombocytopenia and impaired bone marrow megakaryocyte maturation. Prevention of myeloid megakaryocyte maturation disorders: 1. Eat more light, nutritious and easily digestible food. Main and side dishes should be high in protein and vitamins, such as corn, millet, beans, eggs, lean meat, etc. Eat more fresh fruits and vegetables, like spinach, green peppers, oranges, walnuts, red dates, etc. Spicy, greasy and indigestible things are strictly prohibited. Patients in the improvement period should eat soft and fine diet, less hard food and coarse fiber food. Like those who have experienced gastrointestinal bleeding, do not eat food that is too hot. 2, try not to eat drugs that can cause bone marrow megakaryocyte maturation disorder. 3, people with itchy rash disease, can use the lotion for rubbing, so as not to scratch the skin to avoid bringing infection. You should pay attention to skin hygiene, especially in summer to prevent mosquito bites brought about by skin problems. 4, regular life and living, every day try to go to bed early and get up early, and actively participate in physical exercise can enhance physical fitness, increase the ability to resist disease. Patients in the improvement period should choose a gentle exercise program appropriate exercise, like walking, playing tai chi, jogging, etc.. 5, active protection against respiratory infections, rubella, measles, hepatitis and chickenpox and other viral infectious diseases, understand the changing weather conditions, and actively add and subtract clothing to avoid catching a cold or aggravating the disease. 6.Patients with platelet count below 20×109/L should avoid violent collision and prevent different trauma and intracranial hemorrhage.