The difference between calcined oyster and raw oyster exists in different ways. Calcined oyster is the raw oyster to remove impurities in the fire, and the purpose of changing its nature. Calcined oyster is characterized by astringent and astringent, acid control and pain relief, more suitable for application in spontaneous sweating, night sweats, male spermatorrhea, as well as women’s leakage and gastritis, etc., are suitable for treatment with calcined oyster. Raw oyster is characterized by coldness, so its main effects are to re-calm, tranquilize the mind, submerge the yang, tonify the yin, soften hardness and disperse knots, astringent and fix astringency, control acidity and relieve pain. Its therapeutic direction is more for the treatment of hypertension, malignant tumors, these cases can be applied raw oyster, the effect is better. Clinical raw oyster can also treat insomnia, and calcined oyster overlap parts, such as male reproductive system problems, female reproductive system problems, can be treated.