Lack of sleep may increase the amount of urinary protein, resulting in an elevated 24-hour urine protein quantification. Lack of sleep, stress, and sympathetic arousal may cause physiologic proteinuria, but the quantitative amount is less than 500 mg/24h. Physiological proteinuria can be seen in sympathetic nervous excitement, fatigue, strenuous exercise, erectile proteinuria, etc., and most of them can disappear when the cause of elevation is excluded. But at the same time, we should pay special attention to pathological proteinuria, mostly persistent proteinuria, such as acute nephritis, nephrotic syndrome, crush syndrome, diabetes mellitus, heavy metal poisoning, drug damage, systemic lupus erythematosus and so on. When proteinuria is elevated, you should consult a regular hospital in time, complete the relevant examinations, exclude the interfering factors, and carry out standardized treatment for the factors causing proteinuria under the doctor’s judgment, so as to improve the quality of life.