The difference between one and three doses of hepatitis B vaccine is that one dose of hepatitis B vaccine is mostly found in imported vaccines, which are generally more effective. After the one shot, the patient will usually slowly produce hepatitis B surface antibodies in about a month and become immune to chronic viral hepatitis B. However, it is more expensive, at around 200-500 yuan. Generally, the three injections are mostly domestic ordinary hepatitis B vaccine, which requires three injections. For first-time patients, the second dose should be given one month after the first injection, and then the third dose should be given at the end of six months. With three doses of hepatitis B vaccine, patients will mostly establish their own immune protection mechanism and become immune to chronic viral hepatitis B. However, at this time, patients need to have their blood tested for hepatitis B vaccine. However, at this time, the patient needs to have a blood test for the hepatitis B triple system to see if the hepatitis B surface antibody is positive and if the titer is above 10 mIU/mL. If the hepatitis B surface antibody is negative or the titer is below 10mIU/mL, you should actively consider continuing the hepatitis B vaccination for booster until the hepatitis B surface antibody is positive and the titer is above 10mIU/mL. In addition, about 10 years after the vaccination, the patient’s antibodies will be depleted. At this time, patients need to have their hepatitis B system reviewed regularly, and if the titer of hepatitis B surface antibody is less than 10 mIU/mL, they need to continue to receive the hepatitis B vaccine for booster.