There are four possible reasons for waking up in the middle of the night, as follows: first, biological clock disorders, some people’s sleep is not regular or due to the reasons for work, their own habits often stay up late, resulting in biological clock disorders, will lead to frequent waking up at night; second, the problem of the environment, if the sleep environment is not quiet enough, there is often noise or sudden changes in light, etc., will affect sleep, resulting in Third, due to disease, for example, people with sleep apnea syndrome, when lying on their backs at night will cause the back of the tongue to block the airway, resulting in a lack of oxygen to the brain, when the oxygen is reduced to a certain level, it will make the central nervous system excited, and wake up to change positions, this situation will appear often wake up, and long-term chronic diseases, such as arthralgia, migraine and rheumatoid diseases, etc. will Long-term chronic pain, long-term sleep in one position will lead to increased pain, which affects the quality of sleep, resulting in painful waking up in the middle of the night; fourth, due to psychological problems, such as the current work pressure, poor sleep quality, will often wake up at night. In severe cases accompanied by mild depression, the symptoms of early waking will often occur.