There is no evidence of blood-to-blood transmission of neocoronaviruses through wounds, but based on the principle of standard precautions patients with neocoronavirus pneumonia who bleed from wounds should also be considered to be at risk of transmission, and precautions should be strengthened. The main modes of transmission of neocoronavirus pneumonia are droplet, contact, and aerosol transmission. Saliva can contain novel coronaviruses, especially when coughing and speaking, and droplet particles such as saliva can cause transmission, but there is no conclusive evidence of blood-borne transmission, and further observation is needed. However, based on infection control requirements, infectious diseases such as novel coronavirus pneumonia should be regarded as potentially transmissible by blood. Therefore, patients with novel coronavirus pneumonia should avoid direct contact with bleeding wounds, and should take appropriate measures such as wearing masks and gloves as a precautionary measure. Tip: The terms “new coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.