During the National Day holiday, friends chatted about “how can I be paralyzed by a brain hemorrhage without high blood pressure?” The story is that the brain hemorrhage is a stroke. Brain infarction and brain hemorrhage are collectively called “stroke”, also known as “stroke” and “cerebrovascular accident”, which has become the first cause of death in China and the leading cause of disability among Chinese adults. High blood pressure is the most common risk factor, and controlling it is an important controllable tool for stroke prevention. Is it possible to get a stroke without a history of hypertension? Any factor that causes lesions in the brain arteries can be the cause of stroke. (1) small intracranial vascular lesions: aneurysms, arteriovenous malformations, etc.; (2) systemic arterial inflammatory lesions affecting cerebral arteries: multiple aortitis (Takayasu disease), occlusive thrombophlebitis (Buerger disease), nodular arteritis, giant cell arteritis (Horton’s syndrome), systemic lupus erythematosus, etc.; (3) infectious (4) arterial entrapment lesions: traumatic entrapment aneurysms, Marfan syndrome, pseudo-yellow aneurysm entrapment histopathy, etc.; (5) congenital cerebrovascular lesions: moyamoya, congenital arteriovenous malformations, congenital aneurysms; (6) various emboli: rheumatic heart disease with atrial fibrillation Attachment wall thrombus detachment, long bone fracture fat thrombus, air embolism, cancer embolism, etc. So, how to prevent stroke in a targeted way? Currently, a three-tiered prevention strategy is followed: primary prevention includes abstaining from smoking, limiting the salt content of the diet, eating more fresh fruits and vegetables, regular physical activity, and avoiding excessive alcohol consumption to reduce the risk of cardiovascular disease. In addition, pharmacological treatment of diabetes, hypertension and hyperlipidemia is required to reduce the risk of cardiovascular disease and to prevent stroke. Secondary prevention is the early diagnosis and treatment of patients who have had one or more strokes to prevent serious cerebrovascular disease, and the five classes of antihypertensive drugs commonly used for secondary stroke prevention. Tertiary prevention means strengthening rehabilitation care for patients who have already had a stroke to prevent exacerbation. In summary, a low-salt, low-fat diet, smoking cessation, and maintenance of normal weight should be used in general to prevent strokes.