Topical prolongation drugs include Aubracaine Hydrochloride Gel, Compound Lidocaine Cream and so on. 1. Oxybuprocaine hydrochloride gel: oxybuprocaine hydrochloride gel belongs to local anesthetics, which can be used for surface anesthesia and lubrication pain relief. And premature ejaculation patients with oxybuprocaine hydrochloride gel coated on the surface of the glans, can have the effect of delay. It is worth noting that some patients with the drug will appear allergic or toxic reactions, allergic to the components of the oxybuprocaine hydrochloride gel, cardiac and renal insufficiency, patients with myasthenia gravis patients prohibited the use of the drug, and pregnant women and lactating women should be careful to use oxybuprocaine hydrochloride gel. 2. Compound Lidocaine Cream: Compound Lidocaine Cream can be used for cortical local anesthesia, so patients with premature ejaculation applying compound Lidocaine Cream on the genitals can have a delayed effect. Cotrimoxazole cream is contraindicated in people who are allergic to amide local anesthetics, patients with congenital or idiopathic methemoglobinemia, and infants under 3 months of age. Some patients may experience side effects such as skin pallor, edema, and erythema with Compound Lidocaine Cream. It is recommended that you can use topical prolongation medication under the guidance of a doctor, and you should not use medication without authorization to avoid adverse effects on your condition.