Walking with wheezing in advanced stage of lung cancer is mainly related to the invasion of cancer cells into the whole lung, patients should pay attention to bed rest and actively cooperate with doctor’s treatment. In the advanced stage of lung cancer, cancer cells will invade the whole lung and even metastasize to the surrounding organs, thus affecting the normal function of organs, which can be manifested as walking with wheezing. For patients with advanced stage of lung cancer, they should pay attention to bed rest and avoid over exertion; when walking with gasping, they should sit down or semi-recumbent rest, and if necessary, follow doctor’s instruction to inhale oxygen to improve the uncomfortable symptoms. In addition to rest, patients with advanced lung cancer should actively cooperate with doctors in targeted therapy, radiotherapy, chemotherapy, immunotherapy, etc., which can help control the progress of the disease, prolong the survival time, and alleviate the uncomfortable symptoms caused by the disease. If the patient wheezes a lot due to a large amount of phlegm in the respiratory tract, he/she can follow the doctor’s instruction to use aminophylline, aminobromine hydrochloride and other treatments to calm the wheezing and resolve the phlegm, and suction the phlegm when necessary. It is suggested that patients with advanced lung cancer should follow the doctor’s prescription of medication, and should not use medication indiscriminately on their own. They should pay attention to rest, eat a light diet, and go to the doctor for regular checkups.