Nosebleeds in children with leukemia are characterized by spontaneous bleeding that is not easy to stop. Nosebleeds in children with leukemia are due to the rapid deterioration and proliferation of leukemia cells infiltrating hematopoietic tissues, leading to a large reduction in platelets and massive destruction of blood vessel walls, so nosebleeds in children with leukemia are characterized by spontaneous nosebleeds in the absence of touch, while the bleeding is not easy to stop. At this time, the blood routine will indicate a significant reduction in platelets, and a large number of nosebleeds will lead to anemia in children, and intracranial hemorrhage may also occur, leading to the death of the child, which is a serious threat to the child’s life. The child may be treated with transfusion of blood products to replenish platelets. Afterwards, bone marrow aspiration and immunohistochemistry can be performed to identify the cause and type of leukemia, and targeted chemotherapy can be given. When children with leukemia have nosebleeds, they should seek medical treatment as soon as possible. They can be pressed to stop bleeding, and if necessary, they can go to the ear, nose and throat department to stop bleeding.