Crohn’s disease is a chronic inflammatory granulomatous disease that is diagnosed according to six major criteria, primarily through clinical signs, imaging, endoscopy, and pathology. 1. lesions are discontinuous or segmental. 2. endoscopic mucosal lesions are pebbly with formation of longitudinal ulcers and fissure ulcers with a cobblestone-like appearance of the mucosa. 3. Inflammation of the entire intestinal wall with lesions accompanied by abscesses and strictures. 4. The pathologic organization of the mucosa in Crohn’s disease is non-caseating granulomas. 5. The mucosa of the intestinal tract of the patient is often accompanied by the formation of fissures or fistulas. 6. Lesions of the anus, including some refractory ulcers, atypical fistulas or fissures. Crohn’s disease is a kind of intestinal inflammatory disease of unknown cause, mostly seen in the final segment of the ileum and adjacent colon, but from the oral cavity to the anus of all segments of the digestive tract can be involved, segmental distribution, abdominal pain, diarrhea, weight loss as the main clinical manifestations, often with fever, fatigue and other systemic manifestations, perianal abscess or fistulae, such as local manifestations, as well as joints, skin, eyes, oral mucosa and other extra-intestinal damage. Crohn’s disease lacks a gold standard for diagnosis, and diagnosis requires a combination of clinical manifestations, endoscopy, imaging and pathologic histology for comprehensive analysis and follow-up observation. If Crohn’s disease exists, seek timely medical treatment and standardize the treatment under the guidance of doctors to avoid delaying the condition.