Chest pain after satiation is a major manifestation of spontaneous esophageal rupture. Spontaneous esophageal rupture is defined as a sudden increase in pressure in the lumen of the esophagus due to various causes, resulting in a longitudinal tear of the entire left wall of the esophagus adjacent to the diaphragm. It is also known as Boerhaave syndrome, spontaneous esophageal tear syndrome, esophageal pressure rupture, esophageal digestive perforation, and non-traumatic esophageal perforation. Most occur after drinking and vomiting. Then, how to diagnose chest pain after satiety? The following is the diagnostic method of chest pain after satiety: according to the history, clinical symptoms, the corresponding examination, for the next step of diagnosis, treatment to provide a basis: 1, the age of 50 ~ 60 years old middle-aged mostly, infants and young people are less common, men are significantly more than women, about 1:5. 2, the history of the disease is very important to ask for a detailed medical history. Any sudden onset of chest pain or epigastric pain after heavy drinking or satiation should be suspected of the disease. barrett’s triad: shortness of breath, abdominal pain, subcutaneous emphysema of the neck is of great value to the diagnosis. 3, X-ray examination is the most important means of examination, not only can determine whether there is a perforation, but also can localize the perforation. The prognosis of this disease depends on the time of diagnosis, location of rupture, underlying disease, esophageal fundamentals, and the presence or absence of spontaneous mural pleural rupture. Although the mortality rate of Boerhaave’s syndrome has decreased dramatically (31%) since Barrett’s first successful suture of the rupture in 1947, delayed diagnosis can still significantly increase complications, making treatment more difficult and costly, and is the main reason for the high rate of mortality. Clinicians must be highly alert to this disease, observe and think comprehensively, diagnose as early as possible and treat correctly in order to save more patients.