A high basal metabolic rate, often called negative nitrogen balance, means that the three major nutrient metabolites of protein, fat, and sugar ingested by the body cannot meet the needs of consumption, that is, the amount of sugar, protein, and fat needed for consumption far exceeds the amount of ingested content, and thus the body will experience lethargy, fatigue, malnutrition, malabsorption disorders, anemia, and other conditions. Common diseases with high basal metabolic rate include endocrine diseases, usually diabetes mellitus, hyperthyroidism, hyperadrenalism, and several other diseases, especially the thyroid-adrenal-gonadal axis dysregulation before and after menopause and puberty in females as a significant clinical cause, and common tumors, tuberculosis, and other consumptive diseases will also have high basal metabolic rate.