The normal age of menopause averages 49.5 years, with 80% between the ages of 44 and 54. Menopause that occurs before the age of 40 is called premature ovarian failure. Menopause is the permanent cessation of menstruation due to the natural depletion of follicles in the ovaries or the loss of response of the remaining follicles to pituitary gonadotropins, resulting in ovarian failure, and the age of menopause in humans is genetically linked. After menopause, due to the decrease of estrogen level in the body, most women will experience vasoconstriction or neuropsychiatric symptoms, such as hot flashes, sweating, emotional instability, restlessness, irritability, insomnia, and so on, and the symptoms are serious enough to require medication under the guidance of a doctor. Amenorrhea before the age of 40 is called premature ovarian failure, which is characterized by a series of clinical symptoms, so it is necessary to consult the outpatient clinic in a timely manner, and psychological and lifestyle interventions, as well as drug therapy.