Nodules in the lungs with cough need to clarify the cause of the disease, considering possible tuberculosis, pneumonia, lung cancer and other diseases, according to the different causes of anti-tuberculosis, anti-infection and anti-tumor treatment. 1. Tuberculosis: anti-tuberculosis treatment should be targeted and anti-tuberculosis drugs such as rifampicin should be used. 2. Pneumonia: if the lung nodules and cough are caused by lung infection, penicillin or other sensitive antibiotics are usually adopted for anti-infection treatment. 3. Lung cancer: it is also a disease that can cause similar manifestations, and radiotherapy or surgical resection treatment should be chosen according to the specific pathological type and stage. Lung nodules with cough can also be seen in lung fungal disease and other diseases, the specific causes need to be clarified after medical examination, and choose the appropriate treatment according to the doctor’s instructions.