Drugs to reduce muscle tone will have certain side effects, there is no absolute safest drug, you can choose drugs to improve the treatment according to their own situation or follow the doctor’s instructions. For example, tizanidine hydrochloride tablets, baclofen tablets and so on. High muscle tone usually refers to hypertonia, which can be manifested as muscle spasms, etc. Improvement of lower muscle tone usually uses a class of drugs that can relieve muscle spasms and relax muscles. 1. Tizanidine hydrochloride tablets: the main ingredient is tizanidine hydrochloride, which is a kind of central skeletal muscle relaxant. It is suitable for muscle spasm caused by cerebrovascular accident, multiple sclerosis, myasthenia gravis and other conditions. Common side effects include drowsiness, dizziness, and dry mouth. Occasionally, vasodilatation and cardiac arrhythmia are seen. 2. Baclofen Tablet: The main active ingredient is Baclofen, which can be used to treat severe but reversible muscle spasms caused by multiple sclerosis. Common adverse reactions include insomnia, depression, hallucinations, dry mouth, etc. Occasionally, hypotension and bradycardia are seen. It is important to note that when taking the medication, you need to seek immediate medical attention if you experience any serious adverse reactions. In addition, people who are allergic to the above two drugs are forbidden to take them. And the simultaneous use of tizanidine hydrochloride tablets with fluvoxamine or ciprofloxacin drugs is prohibited. Please follow the doctor’s advice before taking the medicine and for special people.