Knee pain after walking is mainly considered to be chondromalacia caused by friction between joints and cartilage after prolonged walking. It is common in young patients after a lot of exercise or in middle-aged and elderly people. With the prolongation of time, the joint degenerates and wears out, the cartilage partially metamorphoses and falls off, and the detached cartilage induces aseptic inflammation in the joint and leads to osteochondritis. The diagnosis can be clearly made by performing magnetic resonance examination, which shows a large amount of edema and high signal on the surface of the joint surface and fluid accumulation in the joint cavity. The treatment is required to reduce the wear and tear of cartilage by resting and reducing activities, which can be effectively recovered in young patients. For elderly patients with significant pain, oral non-steroidal anti-inflammatory drugs such as meloxicam can be taken to improve the symptoms, while oral glucosamine sulfate nutritional cartilage treatment can be given to repair cartilage wear and completely improve the symptoms.