At present, in the clinic, many patients are very concerned about refractory psychosis, are how to treat the problem, and research has found that the onset of psychosis and the limbic system has a correlation, so the main principle in surgical treatment is to block the limbic system’s abnormal neurotransmitters, so as to achieve the elimination of abnormal signals, to achieve the purpose of controlling and alleviating the symptoms. Brain neuromodulation is currently the best means of treating psychosis, and the main methods of surgery include “3+X”, which is currently available.