A lot of closed mouth pimples on the face generally refers to acne, can choose topical drug treatment, chemotherapy, laser treatment and other ways. 1. Topical drug treatment: patients can follow the doctor’s instructions to use retinoic acid drugs for external use, such as adapalene gel, retinoic acid cream, etc., can regulate the differentiation of human epidermal keratinocytes to achieve dissolution of microcomedones, improve sebaceous gland duct keratinization, anti-inflammatory effect, and so on. If accompanied by inflammatory reaction, you can choose to use topical fusidic acid and so on. 2. Chemical treatment: For minor closed mouth acne, fruit acid peeling treatment can be chosen to interfere with the cell surface binding force to reduce the adhesion of keratinocytes, so as to achieve the therapeutic purpose. 3. Laser therapy: Photorejuvenation and other technologies can improve the human skin condition, inhibit the growth of Propionibacterium acnes and reduce the formation of closed mouth acne. It is recommended to consult a doctor in a timely manner. All the above medications should be used under the guidance of a doctor, and should not be used indiscriminately, so as not to lead to adverse consequences.