The difference between dexzopiclone and eszopiclone is that the drug composition is different, the indications are different, the adverse reactions are different, and the contraindications are different. 1. Different drug composition: Dexzopiclone is a non-benzodiazepine hypnotic drug; while Eszopiclone is a moderate-acting benzodiazepine drug. 2. Different indications: Dexzopiclone is suitable for the treatment of various types of insomnia; Eszopiclone is suitable for various types of insomnia and can be used for the treatment of anxiety, nervousness, antiepileptic, anticonvulsant and other treatments, so the therapeutic scope is more extensive. 3. Different adverse reactions: dexzopiclone adverse reactions include headache, dry mouth, dyspepsia, nausea, vertigo, etc.; eszopiclone adverse reactions include dry mouth, drowsiness, dizziness, fatigue, etc., and ataxia and tremor can be found in large doses. 4. Contraindications are different: right zopiclone when using the drug, pay attention to the product and the ingredients contained in the allergy, uncompensated respiratory insufficiency, myasthenia gravis patients, patients with severe sleep apnea syndrome is prohibited; eszopiclone contraindications are different, in addition to allergic to the drug is prohibited, women in pregnancy, patients with severe myasthenia gravis, patients with acute angle-closure glaucoma, and so on, is prohibited. Dexzopiclone and Eszopiclone both need to follow the doctor’s instructions when using the drug, not to self-medicate arbitrarily.