Soreness and swelling in the buttocks after sitting for a while may be caused by hip strain, pyriformis syndrome, sciatic node bursitis, and so on. The cause of the disease is different, the treatment method is different. Common treatments include general treatment, medication, physical therapy and so on. 1. Hip strain: If the hip muscles are over-contracted and fail to take sufficient rest, then the accumulation of muscle and fascia strain and metabolic products will lead to hip soreness when sitting in a chair. You can help relieve hip pain by applying hot compresses and stretching the hips to promote blood circulation and metabolite decomposition. 2. Pyriformis syndrome: Physical therapy can promote blood circulation and relieve pain, such as heat therapy and ultrashort wave. The use of muscle relaxants can relieve the tension of the pyriformis muscle and reduce the pressure on the sciatic nerve, such as botulinum toxin. 3. Sciatic Nodal Bursitis: When a person is sitting, the sciatic nodes are in contact with the stool. When bursitis of the sciatic tuberosity occurs, sitting down will compress the sciatic tuberosity and you will feel pain in your buttocks. Soft cushions can be placed on the seat to avoid prolonged sitting. Use anti-inflammatory medication to relieve pain, such as meloxicam. For severe symptoms, internal bursal closure medication can be injected. In addition, hip pain when sitting in a chair may also be related to sacrococcygeal pain, lumbar spine compression of nerves and so on. It is recommended that the patient go to the hospital in time, and the doctor will diagnose the cause of the disease and give targeted treatment.