Subacute thyroiditis on prednisolone usually takes about 4 weeks, with a reduced dose maintained for 1 to 2 months after symptoms resolve. Subacute thyroiditis, also known as granulomatous thyroiditis, is self-limiting and usually has a favorable prognosis. It is mainly associated with viral infections such as influenza virus, coxsackie virus, etc. In mild or atypical cases, the thyroid gland is only slightly enlarged, and pain and tenderness are mild. There are no systemic symptoms, such as fever, and there may not be clinical signs of thyrotoxicosis or hypothyroidism. The duration of the disease varies from a few weeks to more than half a year, usually about 2 to 3 months. It is a self-limiting disease, and treatment merely relieves symptoms. The use of non-steroidal drugs such as aspirin is usually sufficient to control symptoms. If the symptoms do not improve significantly and are more severe, glucocorticoids may be considered. However, the exact duration of use is recommended under medical supervision. In case of drug allergy, it is recommended to change the drug.