Whether subacute thyroiditis with nodules is serious needs to be divided into circumstances, most subacute thyroiditis has a better prognosis, and nodules have no obvious symptoms, generally not serious; however, individual patients with subacute thyroiditis with nodules, and nodules have an autonomous function, and may occur in the hyperthyroidism or hypothyroidism, in which case it is more serious. Subacute thyroid is usually caused by a viral infection, and the disease has a tendency to heal on its own. Medication is indicated for patients with symptomatic relief or severe disease, such as prednisone, ibuprofen, and propranolol. Most patients with subacute thyroiditis with nodules have a good prognosis, with complete remission within a few weeks or months, and thyroid function can gradually return to normal, with nodules gradually disappearing, which is generally not considered serious; however, individual patients may have permanent hypothyroidism, requiring lifelong treatment with levothyroxine sodium tablets, which is more serious than the former. Patients with subacute thyroiditis with nodules should go to the hospital and cooperate with the doctor for active treatment.