What is the switch phenomenon: The switch phenomenon refers to the fluctuation of the drug effect after long-term application of levodopa drugs in patients with Parkinson’s disease, which is a side effect of this type of drugs. The main manifestation of “off” is the sudden appearance of limb stiffness and inability to move, like a power failure, for example, when walking, suddenly unable to take a step, as if wearing shackles on the feet and lead hammer, struggling to take a step. When “on”, despite the absence of any related treatment, suddenly the activity is normal, the limb stiffness disappears, and the person can move freely. The switching phenomenon is to allow Parkinson’s disease symptoms to switch between sudden remission and sudden exacerbation, often with involuntary movements in remission and generalized stiffness and difficulty in walking in exacerbation. Long-term use of a single therapy or a single drug can often lead to side effects like the “switching” phenomenon. Therefore, even if a patient has been diagnosed, he or she should regularly consult a specialist to adjust the treatment plan. Depending on the type and severity of symptoms and the state of functional impairment, the doctor may be able to reduce these symptoms by following the principle of ‘minimum dose, best effect, long flow, no long-lasting effect’. How Parkinson’s patients can avoid coping with the switch phenomenon: Brain pacemaker implantation is the nemesis of Parkinson’s disease At present, with the continuous development of technology and improvement of medical level, the emergence of brain pacemaker surgery has received a great response and achieved very significant results, which is now internationally recognized as a good method for the treatment of Parkinson’s disease. The side effects of drugs for Parkinson’s disease become apparent after 3-5 years of use, the most common manifestations of which are the symptoms of anisocoria and the switching phenomenon. At this time, the only option for patients who want to continue to control Parkinson’s symptoms and improve their life treatment is surgical therapy. Pacemaker implantation has become a lifesaver for Parkinson’s patients. Pacemaker surgery can extend the “on” time, shorten the “off” time, moderate the sharp fluctuations of “on-off”, eliminate involuntary movements and The “end-of-agent” deterioration effect can be eliminated. Therefore, the combination of pacemaker surgery and drug therapy can achieve better treatment results and improve the quality of life of patients. Pacemaker can reduce the dose of drugs, eliminate or reduce the side effects caused by drugs, increase the “on” time, improve the “off” quality of life, and enhance the ability of daily activities, especially the midline symptoms such as rising, walking, turning, and rolling can be perfectly solved by the pacemaker. Pacemakers have helped countless Parkinson’s patients to get rid of their suffering and gain the ability to take care of themselves.