Pain is the greatest pain in life, which directly affects the quality of life of human beings.In 1936, New York University Bellerue Medical Center opened the world’s first pain diagnosis and treatment center. China’s modern pain diagnosis and treatment work has gone through more than thirty years of course (since the 1980s), China’s pain diagnosis and treatment work to teach the West than, the start is late, but the development is faster. From the beginning of the development of pain diagnosis and treatment, nerve block has been used as an important means of treatment, but nerve block therapy is not a closed therapy, many patients who go to the pain department ask, “Is it a closed needle” as soon as they hear about “nerve block therapy”, “Is it a closed needle”, “Is it a closed needle? “Will the bones become brittle after too many injections?” They think it is a kind of “coping therapy”, which can only temporarily relieve pain. Not only many patients can not distinguish the meaning of “nerve block” and “closed”, even some medical personnel are also confused. In fact, this is a misunderstanding. Closure therapy (also known as Nufcaine closure therapy) originated in the Soviet Union after the October Revolution, is the injection of procaine in the human body’s local pain points, in order to play the role of temporary pain relief. “Closure” is generally used in the treatment of trauma, strain and degenerative osteoarthropathy of muscles, ligaments, fascia, tendon sheaths, bursae, and fibrous canals of bone. Its effects are twofold, namely: (1) protective effect on the nervous system; (2) excitatory effect on the neurotrophic function. Coincidentally, since the 1980s, the domestic development of nerve block treatment, the method is also to puncture injection as the main treatment method, due to a number of people for the “nerve block” and the modern “closure” of the two concepts of confusion, and even think that the nerve block is closure, and thus the nerve block is not the same as closure. Many people are confused between the concepts of “nerve block” and modern “closure”, and even think that nerve block is closure, thus creating misunderstanding and bad impression of nerve block. One of the most controversial issues is the presence of hormones in the medication. There may be some people who do not know much about hormones and think that they will cause osteoporosis, but they have seriously neglected the way of administering the medication, the time of the day, and the control of the amount of the medication. In a monograph on osteoporosis, I found this sentence: “Cortisone 25 mg given every other day, 1 year after the trabecular bone mass reduction of 3.5%”, visible in the pain treatment we use a little bit of hormone is not enough, of course, this is not to say that we can be in the treatment of pain can be used casually hormone, to do neither fear of We should not be afraid of using hormones, but also fully understand the pharmacology and side effects of hormones, rational application, to prevent the problem before it occurs. Nerve block therapy is currently the most basic means of pain treatment, which is to use chemical or physical methods to precisely block nerve conduction and terminate the vicious cycle of pain. Chemical nerve block is mostly carried out with low concentration of local anesthetic, and can also be carried out with high concentration of local anesthetic, ethanol, phenol and other nerve-destroying drugs to achieve long-term analgesic effect. Physical nerve block is commonly used is thermal coagulation therapy, cryotherapy, in addition to mechanical damage method of nerve block, such as facial muscle spasm with facial nerve puncture compression to carry out treatment. The nerve block technique is difficult to operate, complex, and requires precision, and is applicable to a variety of painful and non-painful disorders (e.g., spasticity, paralysis, etc.). Nerve block is not only used for analgesia and treatment in clinic, but also for diagnosis, prognosis and disease prevention. Since nerve block is directly acting on the nerves, if it is not operated properly, it will cause more serious complications and even life-threatening. Therefore, the nerve block treatment is not anyone can do, must be received by the formal training and clinical experience of the doctor operation. 1, the use of different drugs “closed” generally use a higher concentration of anesthetic, and “nerve block” generally only use a lower concentration of anesthetic can achieve the therapeutic effect, so there will be no dysfunction of the limbs; in addition, the general “Closed” injection drugs generally only contain anesthetic, while “nerve block” generally use some of the lesion tissue has a direct therapeutic effect of drugs, as well as neurotrophic drugs and so on. 2, different parts of the closed injection site is the site of pain, equivalent to the target area of nerve block block, nerve block is according to the law of the nerve course and innervation of the drug injection, such as clinically commonly used stellate ganglion block, the treatment site is in the neck, but can be treated for neurasthenia, insomnia, sympathetic cervical spondylosis, hypertension, facial paralysis and other dozen kinds of difficult diseases. 3, the difficulty of technical operation and efficacy of different “closed” just inject the drug into the lesion site proximal or nearby to achieve the purpose, and even “where the pain hit which”, the precision requirements are not high. The “nerve block” is a branch operation that must undergo a long period of professional training to be implemented correctly, therefore, the treatment must be clearly diagnosed before treatment, to find the precise location of the lesion site, the heart must be injected accurately into the lesion tissue or around the therapeutic drugs, in order to achieve the desired effect of treatment. 4, different requirements for diagnosis It is generally believed that the “closed” therapy is based on the pain closed to block the continuation of the arc of pain, the diagnosis before injection is not necessarily clear, the injection site is not necessarily the lesion, so the diagnosis is not clear can also be carried out, and often the pain is reduced, but the lesion can still have development. On the other hand, before administering “nerve block” therapy, the diagnosis must be clear, the location of the lesion must be known, and the drug must be injected into the lesion. Therefore, the efficacy of the two treatments cannot be compared with each other. The characteristic of “nerve block” therapy is that “the most needed drugs are delivered to the most needed places in the most direct way and with great accuracy”. Therefore, “nerve block” is a non-surgical treatment that focuses on the advantages of medication, fights a war of annihilation and rapid warfare, and achieves fast results with high efficacy and fewer visits to the hospital by the patient. It can be seen that the two are completely irrelevant to the two concepts, but also two very different treatment methods, nerve block therapy as the most basic means of pain treatment, can play a greater role for the majority of pain patients to relieve their pain.